Patient: Cardiac Disease: Medical Terminology
Abrupt Closure: Obstructed coronary flow in the dilated lesion that was previously documented to be patent with antegrade flow. This can be detected post interventional procedure or at a follow-up time period.
Aneurysm: angiographically defined as an expansion of the lumen by at least 20% compared with the normal lumen dimensions in the treatment region that extends with a wide or narrow mouth beyond the apparent normal contour.
Brachytherapy: in radiotherapy, treatment with ionizing radiation whose source is applied to the surface of the body or is located a short distance from the body area being treated.
Coronary Spasm: Transient or permanent narrowing > 50% in a region where <25% stenosis had previously been noted. This can be detected after any interventional procedure or at a follow-up time period.
Dissection: Dissection is assessed by graded levels of luminal abnormality in the contrast column in the dilated segment based on mild, moderate and severe, or by the NHLBI criteria (e.g., Types A - luminal haziness to Type F - dissection with total occlusion.
Gy = Gray: a unit of absorbed radiation dose, i.e the energy deposited/unit mass of the absorbing medium. 1 Gy = 100 Centigray (cGy) = 100 rad
Hyperplasia: An increase in the number of cells in a tissue due to increased cell division. This occurs in normal growth, as well as in response to wound injury or tumor growth.
Keloid: a sharply elevated, irregularly shaped, progressively enlarging scar due to the formation of excessive amounts of collagen in the corium during connective tissue repair.
MeV: megaelectron volt
mRem = millirem: a measure of radiation dose equivalence; the effect on tissue of various types of radiation.
Myocardial infarction: the presence of new Q waves or elevation of the CPK to greater than two times the baseline with the MB fraction greater than twice the normal value defined by the clinical laboratory.
Patency: the condition of being widely open.
Perforation: Extravasation of contrast outside the arterial lumen; identified as localized or non-localized.
PTCA: defined as revascularization by balloon angioplasty, directional and rotational atherectomy and excimer laser.
Pterygium: a wing-shaped fibrovascular proliferation of the bulbar conjunctiva.
Restenosis: A dichotomous binary endpoint that is defined as >50% lumen reduction in the treated lesion when compared to reference luminal diameter 8 months after initial treatment, however a more detailed breakdown of luminal dimensions (% MLD) will be measured.
Site Thrombosis: myocardial infarction attributable to the target vessel with angiographic documentation (site-reported or by QCA) of thrombus or total occlusion at the target site >30 days after the index procedure in the absence of an intervening revascularization of the target vessel.
Stent Thrombosis: angiographic thrombus or subactue closure within the target vessel at the time of the clinically driven angiographic restudy for documented ischemia (chest pain and ECG changes). Any death not attributed to a non-cardiac cause within the first 30 days will be considered a surrogate for thrombosis in the absence of documented angiographic stent patency.
90Strontium: Radioactive isotope of Strontium with a physical half-life of 28.1 years and a low-average energy (0.2 MeV). Its decay product (90Yttrium) has a 64 hour half-life, and an energy of 2.27 MeV.
Thrombus: discrete angiographic filling defect with or without staining.
Total Occlusion: a minimal lumen diameter of zero at follow-up as assessed by QCA.